FOXO4-DRI (Proxofim) – D-Retro-Inverso

FOXO4-DRI (FOXO4 D-Retro-Inverso peptide), also known by the development code Proxofim, is a synthetic cell-penetrating peptide (CPP) engineered as a retro-inverso (DRI) analog of a FOXO4 peptide fragment. In research literature, it has been studied for its interaction with the FOXO4–p53 protein complex in cellular senescence models.

The retro-inverso (DRI) configuration means the peptide is composed entirely of D-amino acids arranged in reverse sequence relative to the original L-peptide. This structural modification is designed to enhance resistance to enzymatic degradation in experimental settings.

Research Use Only: This material is supplied strictly for laboratory developmental research use. It is not intended for human or veterinary consumption.

Scientific Classification

• Common Name: FOXO4-DRI
• Development Code: Proxofim
• Scientific Name: FOXO4 D-Retro-Inverso Peptide
• Classification: Cell-penetrating peptide (CPP); peptide antagonist; p53 interaction modulator (research context)

Chemical & Structural Information

• Molecular Formula: C₂₂₈H₃₈₈N₈₆O₆₄
• Molecular Weight: ~5358.05 g/mol
• Peptide Type: Synthetic D-amino acid retro-inverso peptide
• Structural Feature: Designed for increased proteolytic stability in laboratory models

Research Context

Within controlled laboratory environments, FOXO4-DRI has been investigated in studies examining:

• FOXO4–p53 protein interaction pathways
• Cellular senescence signaling models
• Apoptosis-related molecular mechanisms
• Protein–protein interaction disruption research
• Cell-penetrating peptide delivery systems

The peptide is engineered to interfere with specific intracellular protein interactions in vitro. All descriptions above are limited strictly to experimental and mechanistic research contexts.

No therapeutic or medical claims are made.

Product Classification

• Category: Synthetic Research Peptide
• Intended Use: Laboratory and developmental research only
• Form: Supplied as research-grade raw material (refer to product label for preparation details)

Regulatory Status

This product is not approved by the U.S. Food and Drug Administration (FDA) for the diagnosis, treatment, cure, or prevention of any disease.

This material is sold exclusively for laboratory research purposes.

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Research Use Only

All products are for laboratory developmental research USE ONLY. Products are not for human consumption. Use of these products in such a manner other than research violates the terms of service.

Legal Disclaimer

This product is sold as a pure compound for research purposes only and is not for use as a dietary supplement. Please refer to the terms and conditions prior to purchase.

Safety Information

Keep this product out of the reach of children. This material has limited research available and may result in adverse effects if improperly handled or consumed.

This product is not a dietary supplement but a pure substance sold as a raw material. We attest to the quality, purity, and description of the materials we provide. This product is intended for persons with the knowledge and equipment to safely handle laboratory materials.

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