IGF-1 LR3 (Long Arginine 3–Insulin-like Growth Factor-1) – Research Peptide

IGF-1 LR3 (Long R3 Insulin-like Growth Factor-1), also referred to as LR3-IGF-1, is a synthetic 83–amino acid analog of human IGF-1 engineered for extended stability in laboratory research models.

This modified peptide contains two primary structural alterations:

• Addition of 13 amino acids at the N-terminus
• Substitution of arginine (Arg) for glutamic acid (Glu) at position 3 (Arg3 modification)

In research literature, these modifications are described as reducing affinity for IGF-binding proteins (IGFBPs), thereby extending experimental half-life compared to native IGF-1 in controlled models.

Research Use Only: This material is supplied strictly for laboratory developmental research use. It is not intended for human or veterinary consumption.

Scientific Classification

• Scientific Name: Long Arginine 3–Insulin-like Growth Factor-1
• Abbreviations: IGF-1 LR3; LR3-IGF-1
• Classification: Recombinant synthetic polypeptide / growth factor analog (research context)
• Peptide Length: 83 amino acids

Chemical & Structural Information

• Molecular Formula: C₄₀₀H₆₂₅N₁₁₁O₁₁₅S₉
• Molecular Weight: ~9.1 kDa (9,117.6 Da)
• Structure Type: Extended IGF-1 analog with Arg3 substitution

Research Context

Within controlled laboratory environments, IGF-1 LR3 has been examined in studies involving:

• IGF-1 receptor (IGF-1R) pathway signaling models
• Cell proliferation and differentiation research
• Protein-binding affinity analysis (IGFBP interaction studies)
• Receptor activation kinetics investigations
• Endocrine signaling pathway research

Reported experimental data suggests extended activity in vitro compared to native IGF-1 due to reduced binding to inhibitory binding proteins. All references above are limited strictly to laboratory and investigational research contexts.

No therapeutic or medical claims are made.

Product Classification

• Category: Synthetic Research Polypeptide
• Form: Research-grade raw material (refer to product label for preparation details)
• Intended Use: Laboratory and developmental research only

Regulatory Status

This product is not approved by the U.S. Food and Drug Administration (FDA) for the diagnosis, treatment, cure, or prevention of any disease.

This material is sold exclusively for laboratory research purposes.

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The statements made within this website have not been evaluated by the US Food and Drug Administration. The statements and the products of this company are not intended to diagnose, treat, cure or prevent any disease.

The information in this website is for educational purposes only and is not intended as medical or research advice.

Research Use Only

All products are for laboratory developmental research USE ONLY. Products are not for human consumption. Use of these products in such a manner other than research violates the terms of service.

Legal Disclaimer

This product is sold as a pure compound for research purposes only and is not for use as a dietary supplement. Please refer to the terms and conditions prior to purchase.

Safety Information

Keep this product out of the reach of children. This material has limited research available and may result in adverse effects if improperly handled or consumed.

This product is not a dietary supplement but a pure substance sold as a raw material. We attest to the quality, purity, and description of the materials we provide. This product is intended for persons with the knowledge and equipment to safely handle laboratory materials.

You agree to indemnify us for any adverse effects that may arise from improper handling and/or consumption of this product.

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