PE-22-28 (Mini-Spadin) – Synthetic Heptapeptide | Research Use Only

PE-22-28, also known as Mini-Spadin, is a synthetic heptapeptide composed of seven amino acids. In research literature, it is described as a selective inhibitor of the TREK-1 (K2P2.1) two-pore domain potassium channel.

PE-22-28 is a truncated synthetic fragment derived from the endogenous peptide spadin, which itself originates from the pro-peptide sortilin. It is studied in laboratory models evaluating ion channel modulation and neuronal signaling pathways.

Research Use Only: This material is supplied strictly for laboratory developmental research use. It is not intended for human or veterinary consumption.

Scientific Classification

• Common Name: PE-22-28
• Alternate Name: Mini-Spadin
• Classification: Synthetic heptapeptide (oligopeptide)
• Functional Classification (Research Context): Selective TREK-1 (K2P2.1) channel inhibitor
• Biological Origin: Fragment derived from endogenous spadin (sortilin pro-peptide derivative)

Chemical & Structural Information

• Amino Acid Sequence: Gly-Val-Ser-Trp-Gly-Leu-Arg (GVSWGLR)
• Molecular Weight (Free Form): ~773.9 Da
• Molecular Weight (Acetate / Optimized Forms): ~802.94 Da (varies by salt form)
• Scientific (IUPAC) Name: (2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[(2-aminoacetyl)amino]-3-methylbutanoyl]amino]-3-hydroxypropanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]acetyl]amino]-4-methylpentanoyl]amino]-5-(diaminomethylideneamino)pentanoic acid

Research Context

Within controlled laboratory environments, PE-22-28 has been examined in studies involving:

• TREK-1 (K2P2.1) potassium channel inhibition models
• Two-pore domain potassium (K2P) channel research
• Ion channel modulation investigations
• Neuronal excitability pathway analysis
• Structure–activity relationship (SAR) studies of spadin-derived peptides

PE-22-28 is referenced in experimental research exploring selective modulation of potassium channels and related intracellular signaling mechanisms. All descriptions above are limited strictly to laboratory and investigational research contexts.

No therapeutic or medical claims are made.

Product Classification

• Category: Synthetic Research Peptide
• Form: Research-grade raw material (refer to product label for preparation details)
• Intended Use: Laboratory and developmental research only

Regulatory Status

This product is not approved by the U.S. Food and Drug Administration (FDA) for the diagnosis, treatment, cure, or prevention of any disease.

This material is sold exclusively for laboratory research purposes.

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Research Use Only

All products are for laboratory developmental research USE ONLY. Products are not for human consumption. Use of these products in such a manner other than research violates the terms of service.

Legal Disclaimer

This product is sold as a pure compound for research purposes only and is not for use as a dietary supplement. Please refer to the terms and conditions prior to purchase.

Safety Information

Keep this product out of the reach of children. This material has limited research available and may result in adverse effects if improperly handled or consumed.

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