PNC-27 – Synthetic 32-Amino Acid Chimeric Peptide | Research Use Only

PNC-27 is a 32-amino acid synthetic chimeric peptide composed of two functional domains:

• A segment derived from the p53 tumor-suppressor protein (amino acid residues 12–26; sequence: PPLSQETFSDLWKLL), representing the HDM-2 binding region
• A membrane residency / cell-penetrating peptide (CPP) leader sequence derived from the antennapedia protein, designed to facilitate intracellular and membrane localization in experimental systems

This dual-domain structure classifies PNC-27 as a membrane-active and cell-penetrating research peptide.

Research Use Only: This material is supplied strictly for laboratory developmental research use. It is not intended for human or veterinary consumption.

Scientific Classification

• Common Name: PNC-27
• Classification: Membrane-active peptide; Cell-penetrating peptide (CPP)
• Structural Type: 32-amino acid chimeric peptide
• Functional Domains: p53-derived binding region + membrane residency peptide (MRP)

Chemical & Structural Information

• Molecular Weight (Free Base): ~4031.72 g/mol
• Molecular Formula: C₁₈₈H₂₉₃N₅₃O₄₄S
• Amino Acid Sequence:
  H-Pro-Pro-Leu-Ser-Gln-Glu-Thr-Phe-Ser-Asp-Leu-Trp-Lys-Leu-Leu-Lys-Lys-Trp-Lys-Met-Arg-Arg-Asn-Gln-Phe-Trp-Val-Lys-Val-Gln-Arg-Gly-OH
• Physical Appearance: White lyophilized (freeze-dried) powder

Research Context

Within controlled laboratory environments, PNC-27 has been examined in studies involving:

• p53 pathway interaction models
• HDM-2 binding region research
• Membrane localization and peptide internalization studies
• Cell-penetrating peptide (CPP) transport investigations
• Structure–activity relationship (SAR) analysis of chimeric peptides

PNC-27 is frequently referenced in experimental research evaluating membrane-active peptides and intracellular targeting mechanisms in vitro.

No therapeutic or medical claims are made. All descriptions above are limited strictly to laboratory and investigational research contexts.

Product Classification

• Category: Synthetic Research Peptide
• Form: Lyophilized powder
• Intended Use: Laboratory and developmental research only

Regulatory Status

This product is not approved by the U.S. Food and Drug Administration (FDA) for the diagnosis, treatment, cure, or prevention of any disease.

This material is sold exclusively for laboratory research purposes.

FDA Disclaimer

The statements made within this website have not been evaluated by the US Food and Drug Administration. The statements and the products of this company are not intended to diagnose, treat, cure or prevent any disease.

The information in this website is for educational purposes only and is not intended as medical or research advice.

Research Use Only

All products are for laboratory developmental research USE ONLY. Products are not for human consumption. Use of these products in such a manner other than research violates the terms of service.

Legal Disclaimer

This product is sold as a pure compound for research purposes only and is not for use as a dietary supplement. Please refer to the terms and conditions prior to purchase.

Safety Information

Keep this product out of the reach of children. This material has limited research available and may result in adverse effects if improperly handled or consumed.

This product is not a dietary supplement but a pure substance sold as a raw material. We attest to the quality, purity, and description of the materials we provide. This product is intended for persons with the knowledge and equipment to safely handle laboratory materials.

You agree to indemnify us for any adverse effects that may arise from improper handling and/or consumption of this product.

The articles and information on products that may be found on this website are provided exclusively for informational and educational purposes. These items are not pharmaceuticals or medications, and the Food and Drug Administration has not given permission for the treatment or prevention of any disease, medical condition, or ailment using them.