{"product_id":"pe-22-28-10mg","title":"PE-22-28- 10MG","description":"\u003ch1\u003ePE-22-28 (Mini-Spadin) – Synthetic Heptapeptide | Research Use Only\u003c\/h1\u003e\n\u003cp\u003e\u003cstrong\u003ePE-22-28\u003c\/strong\u003e, also known as\u003cspan\u003e \u003c\/span\u003e\u003cstrong\u003eMini-Spadin\u003c\/strong\u003e, is a synthetic heptapeptide composed of seven amino acids. In research literature, it is described as a selective inhibitor of the\u003cspan\u003e \u003c\/span\u003e\u003cstrong\u003eTREK-1 (K2P2.1) two-pore domain potassium channel\u003c\/strong\u003e.\u003c\/p\u003e\n\u003cp\u003ePE-22-28 is a truncated synthetic fragment derived from the endogenous peptide spadin, which itself originates from the pro-peptide sortilin. It is studied in laboratory models evaluating ion channel modulation and neuronal signaling pathways.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eResearch Use Only:\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003eThis material is supplied strictly for laboratory developmental research use. It is not intended for human or veterinary consumption.\u003c\/p\u003e\n\u003chr\u003e\n\u003ch2\u003eScientific Classification\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eCommon Name:\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003ePE-22-28\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAlternate Name:\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003eMini-Spadin\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eClassification:\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003eSynthetic heptapeptide (oligopeptide)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFunctional Classification (Research Context):\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003eSelective TREK-1 (K2P2.1) channel inhibitor\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBiological Origin:\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003eFragment derived from endogenous spadin (sortilin pro-peptide derivative)\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr\u003e\n\u003ch2\u003eChemical \u0026amp; Structural Information\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eAmino Acid Sequence:\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003eGly-Val-Ser-Trp-Gly-Leu-Arg (GVSWGLR)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular Weight (Free Form):\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003e~773.9 Da\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular Weight (Acetate \/ Optimized Forms):\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003e~802.94 Da (varies by salt form)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eScientific (IUPAC) Name:\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003e(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[(2-aminoacetyl)amino]-3-methylbutanoyl]amino]-3-hydroxypropanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]acetyl]amino]-4-methylpentanoyl]amino]-5-(diaminomethylideneamino)pentanoic acid\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr\u003e\n\u003ch2\u003eResearch Context\u003c\/h2\u003e\n\u003cp\u003eWithin controlled laboratory environments, PE-22-28 has been examined in studies involving:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eTREK-1 (K2P2.1) potassium channel inhibition models\u003c\/li\u003e\n\u003cli\u003eTwo-pore domain potassium (K2P) channel research\u003c\/li\u003e\n\u003cli\u003eIon channel modulation investigations\u003c\/li\u003e\n\u003cli\u003eNeuronal excitability pathway analysis\u003c\/li\u003e\n\u003cli\u003eStructure–activity relationship (SAR) studies of spadin-derived peptides\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003ePE-22-28 is referenced in experimental research exploring selective modulation of potassium channels and related intracellular signaling mechanisms. All descriptions above are limited strictly to laboratory and investigational research contexts.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eNo therapeutic or medical claims are made.\u003c\/strong\u003e\u003c\/p\u003e\n\u003chr\u003e\n\u003ch2\u003eProduct Classification\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eCategory:\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003eSynthetic Research Peptide\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eForm:\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003eResearch-grade raw material (refer to product label for preparation details)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eIntended Use:\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003eLaboratory and developmental research only\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr\u003e\n\u003ch2\u003eRegulatory Status\u003c\/h2\u003e\n\u003cp\u003eThis product is not approved by the U.S. Food and Drug Administration (FDA) for the diagnosis, treatment, cure, or prevention of any disease.\u003c\/p\u003e\n\u003cp\u003eThis material is sold exclusively for laboratory research purposes.\u003c\/p\u003e\n\u003chr\u003e\n\u003ch2\u003eFDA Disclaimer\u003c\/h2\u003e\n\u003cp\u003eThe statements made within this website have not been evaluated by the US Food and Drug Administration. The statements and the products of this company are not intended to diagnose, treat, cure or prevent any disease.\u003c\/p\u003e\n\u003cp\u003eThe information in this website is for educational purposes only and is not intended as medical or research advice.\u003c\/p\u003e\n\u003chr\u003e\n\u003ch2\u003eResearch Use Only\u003c\/h2\u003e\n\u003cp\u003eAll products are for laboratory developmental research USE ONLY. Products are not for human consumption. Use of these products in such a manner other than research violates the terms of service.\u003c\/p\u003e\n\u003chr\u003e\n\u003ch2\u003eLegal Disclaimer\u003c\/h2\u003e\n\u003cp\u003eThis product is sold as a pure compound for research purposes only and is not for use as a dietary supplement. Please refer to the terms and conditions prior to purchase.\u003c\/p\u003e\n\u003chr\u003e\n\u003ch2\u003eSafety Information\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eKeep this product out of the reach of children.\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003eThis material has limited research available and may result in adverse effects if improperly handled or consumed.\u003c\/p\u003e\n\u003cp\u003eThis product is not a dietary supplement but a pure substance sold as a raw material. We attest to the quality, purity, and description of the materials we provide. This product is intended for persons with the knowledge and equipment to safely handle laboratory materials.\u003c\/p\u003e\n\u003cp\u003eYou agree to indemnify us for any adverse effects that may arise from improper handling and\/or consumption of this product.\u003c\/p\u003e\n\u003cp\u003eThe articles and information on products that may be found on this website are provided exclusively for informational and educational purposes. These items are not pharmaceuticals or medications, and the Food and Drug Administration has not given permission for the treatment or prevention of any disease, medical condition, or ailment using them.\u003c\/p\u003e","brand":"YourBrand","offers":[{"title":"Default Title","offer_id":52414647238932,"sku":null,"price":55.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1007\/4066\/1524\/files\/PE-22-28-10mg.png?v=1777564885","url":"https:\/\/xxxpeptides.com\/products\/pe-22-28-10mg","provider":"xxxpeptides","version":"1.0","type":"link"}